Ontology highlight
ABSTRACT:
SUBMITTER: Stumpff J
PROVIDER: S-EPMC3242732 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Stumpff Jason J Duncan Tod T Homola Ellen E Campbell Shelagh D SD Su Tin Tin TT
Current biology : CB 20041201 23
Cyclin-dependent kinases (Cdks) are the central regulators of the cell division cycle. Inhibitors of Cdks ensure proper coordination of cell cycle events and help regulate cell proliferation in the context of tissues and organs. Wee1 homologs phosphorylate a conserved tyrosine to inhibit the mitotic cyclin-dependent kinase Cdk1. Loss of Wee1 function in fission or budding yeast causes premature entry into mitosis. The importance of metazoan Wee1 homologs for timing mitosis, however, has been dem ...[more]