Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC3115953 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Wang Longfei L Zhao Fei F Li Mei M Zhang Hongmei H Gao Yu Y Cao Peng P Pan Xiaowei X Wang Zhuanhua Z Chang Wenrui W
PloS one 20110615 6
BWI-1 (buckwheat trypsin inhibitor), a member of the potato inhibitor I family, suppresses the growth of T-acute lymphoblastic leukemia cells and induces apoptosis in human solid tumor cell lines. Here, we report the crystal structure of rBTI (recombinant buckwheat trypsin inhibitor), a recombinant protein of BWI-1, at 1.84 Å resolution and the structure of rBTI in complex with bovine trypsin at 2.26 Å resolution. A conformational change of Trp53 at the P(8)' position in rBTI was observed upon i ...[more]