Ontology highlight
ABSTRACT:
SUBMITTER: Pozzi N
PROVIDER: S-EPMC3423485 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Current opinion in structural biology 20120603 4
For over four decades, two competing mechanisms of ligand recognition--conformational selection and induced-fit--have dominated our interpretation of protein allostery. Defining the mechanism broadens our understanding of the system and impacts our ability to design effective drugs and new therapeutics. Recent kinetics studies demonstrate that trypsin-like proteases exist in equilibrium between two forms: one fully accessible to substrate (E) and the other with the active site occluded (E*). Ana ...[more]