Ontology highlight
ABSTRACT:
SUBMITTER: Li SL
PROVIDER: S-EPMC3116169 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Li Shun-Lai SL He Mao-Yu MY Du Hong-Guang HG
International journal of molecular sciences 20110510 5
The active metabolite of the novel immunosuppressive agent leflunomide has been shown to inhibit the enzyme dihydroorotate dehydrogenase (DHODH). This enzyme catalyzes the fourth step in de novo pyrimidine biosynthesis. Self-organizing molecular field analysis (SOMFA), a simple three-dimensional quantitative structure-activity relationship (3D-QSAR) method is used to study the correlation between the molecular properties and the biological activities of a series of analogues of the active metabo ...[more]