Ontology highlight
ABSTRACT:
SUBMITTER: Pasque V
PROVIDER: S-EPMC3116279 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Pasque Vincent V Gillich Astrid A Garrett Nigel N Gurdon John B JB
The EMBO journal 20110506 12
How various layers of epigenetic repression restrict somatic cell nuclear reprogramming is poorly understood. The transfer of mammalian somatic cell nuclei into Xenopus oocytes induces transcriptional reprogramming of previously repressed genes. Here, we address the mechanisms that restrict reprogramming following nuclear transfer by assessing the stability of the inactive X chromosome (Xi) in different stages of inactivation. We find that the Xi of mouse post-implantation-derived epiblast stem ...[more]