Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC3116285 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Chen Zhong Z Zhang Chunpeng C Wu Dayong D Chen Hongyan H Rorick Anna A Zhang Xiaoting X Wang Qianben Q
The EMBO journal 20110510 12
The UBE2C oncogene is overexpressed in many types of solid tumours including the lethal castration-resistant prostate cancer (CRPC). The underlying mechanisms causing UBE2C gene overexpression in CRPC are not fully understood. Here, we show that CRPC-specific enhancers drive UBE2C overexpression in both AR-negative and -positive CRPC cells. We further show that co-activator MED1 recruitment to the UBE2C enhancers is required for long-range UBE2C enhancer/promoter interactions. Importantly, we fi ...[more]