Ontology highlight
ABSTRACT:
SUBMITTER: Patel R
PROVIDER: S-EPMC5887544 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Patel Rachana R Fleming Janis J Mui Ernest E Loveridge Carolyn C Repiscak Peter P Blomme Arnaud A Harle Victoria V Salji Mark M Ahmad Imran I Teo Katy K Hamdy Freddie C FC Hedley Ann A van den Broek Niels N Mackay Gillian G Edwards Joanne J Sansom Owen J OJ Leung Hing Y HY
EMBO molecular medicine 20180401 4
Metastatic castration-resistant prostate cancer (mCRPC) is a lethal form of treatment-resistant prostate cancer and poses significant therapeutic challenges. Deregulated receptor tyrosine kinase (RTK) signalling mediated by loss of tumour suppressor Sprouty2 (SPRY2) is associated with treatment resistance. Using pre-clinical human and murine mCRPC models, we show that SPRY2 deficiency leads to an androgen self-sufficient form of CRPC Mechanistically, HER2-IL6 signalling axis enhances the express ...[more]