Ontology highlight
ABSTRACT:
SUBMITTER: Emanuele MJ
PROVIDER: S-EPMC3116415 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Emanuele Michael J MJ Ciccia Alberto A Elia Andrew E H AE Elledge Stephen J SJ
Proceedings of the National Academy of Sciences of the United States of America 20110531 24
The anaphase-promoting complex/cyclosome (APC/C) is a cell cycle-regulated E3 ubiquitin ligase that controls the degradation of substrate proteins at mitotic exit and throughout the G1 phase. We have identified an APC/C substrate and cell cycle-regulated protein, KIAA0101/PAF15. PAF15 protein levels peak in the G2/M phase of the cell cycle and drop rapidly at mitotic exit in an APC/C- and KEN-box-dependent fashion. PAF15 associates with proliferating cell nuclear antigen (PCNA), and depletion of ...[more]