Ontology highlight
ABSTRACT:
SUBMITTER: Kops GJ
PROVIDER: S-EPMC2864710 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Kops Geert J P L GJ van der Voet Monique M Manak Michael S MS van Osch Maria H J MH Naini Said M SM Brear Andrea A McLeod Ian X IX Hentschel Dirk M DM Yates John R JR van den Heuvel Sander S Shah Jagesh V JV
Journal of cell science 20100414 Pt 10
Error-free chromosome segregation depends on timely activation of the multi-subunit E3 ubiquitin ligase APC/C. Activation of the APC/C initiates chromosome segregation and mitotic exit by targeting critical cell-cycle regulators for destruction. The APC/C is the principle target of the mitotic checkpoint, which prevents segregation while chromosomes are unattached to spindle microtubules. We now report the identification and characterization of APC16, a conserved subunit of the APC/C. APC16 was ...[more]