Ontology highlight
ABSTRACT:
SUBMITTER: Pettit GR
PROVIDER: S-EPMC3116808 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Pettit George R GR Hogan Fiona F Toms Steven S
Journal of natural products 20110502 5
The dolastatin series of unique peptides, originally discovered as constituents of the sea hare Dolabella auricularia, is of increasing importance in providing biological leads, especially to new and useful anticancer drugs. Dolastatin 10 and three analogues, minor structural modifications designated auristatins, are currently in human cancer clinical trials. The present study was undertaken to explore delivery to the cancer sites by way of phosphate or quinoline modifications. The initial objec ...[more]