Ontology highlight
ABSTRACT:
SUBMITTER: Pettit GR
PROVIDER: S-EPMC3251507 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Pettit George R GR Meng Yanhui Y Herald Delbert L DL Knight John C JC Day John F JF
Journal of natural products 20050801 8
Bioassay (P388 lymphocytic leukemia cell line and human cancer cell lines) guided separation of an extract prepared from the previously chemically uninvestigated Texas grasshopper Brachystola magna led to isolation of the cancer cell growth inhibitory pancratistatin (1), narciclasine (2), and ungeremine (3). Pancratistatin (1) was first isolated from the bulbs of Hymenocallis littoralis), and the original crystal structure was deduced by X-ray analysis of a monomethyl ether derivative. In the pr ...[more]