Ontology highlight
ABSTRACT:
SUBMITTER: Bethge WA
PROVIDER: S-EPMC3116939 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Bethge W A WA Kerbauy F R FR Santos E E Gooley T A TA Storb R R Sandmaier B M BM
Bone marrow transplantation 20101213 10
Extracorporeal photopheresis (ECP) and the purine analog pentostatin exert potent immunomodulatory effects, but have not been evaluated for their ability to enhance engraftment of hematopoietic stem cells. We evaluated, in a canine model of dog leukocyte antigen (DLA)-identical hematopoietic cell transplantation (HCT), whether ECP in combination with pentostatin could enhance engraftment using a nonmyeloablative regimen consisting of 100 cGy TBI and postgrafting immunosuppression with mycophenol ...[more]