Ontology highlight
ABSTRACT:
SUBMITTER: Shaughnessy PJ
PROVIDER: S-EPMC3376382 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Shaughnessy P J PJ Bolwell B J BJ van Besien K K Mistrik M M Grigg A A Dodds A A Prince H M HM Durrant S S Ilhan O O Parenti D D Gallo J J Foss F F Apperley J J Zhang M-J MJ Horowitz M M MM Abhyankar S S
Bone marrow transplantation 20091116 6
GVHD is partly mediated by host APCs that activate donor T cells. Extracorporeal photopheresis (ECP) can modulate APC function and benefit some patients with GVHD. We report the results of a study using ECP administered before a standard myeloablative preparative regimen intended to prevent GVHD. Grades II-IV acute GVHD developed in 9 (30%) of 30 recipients of HLA-matched related transplants and 13 (41%) of 32 recipients of HLA-matched unrelated or HLA-mismatched related donor transplants. Actua ...[more]