Ontology highlight
ABSTRACT:
SUBMITTER: Calderon CP
PROVIDER: S-EPMC3117255 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Calderon Christopher P CP Martinez Josue G JG Carroll Raymond J RJ Sorensen Danny C DC
Multiscale modeling & simulation : a SIAM interdisciplinary journal 20100101 4
Time series associated with single-molecule experiments and/or simulations contain a wealth of multiscale information about complex biomolecular systems. We demonstrate how a collection of Penalized-splines (P-splines) can be useful in quantitatively summarizing such data. In this work, functions estimated using P-splines are associated with stochastic differential equations (SDEs). It is shown how quantities estimated in a single SDE summarize fast-scale phenomena, whereas variation between cur ...[more]