A genome-wide association study of DSM-IV cannabis dependence.
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ABSTRACT:
SUBMITTER: Agrawal A
PROVIDER: S-EPMC3117436 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
A genome-wide association study of DSM-IV cannabis dependence.
Agrawal Arpana A Lynskey Michael T MT Hinrichs Anthony A Grucza Richard R Saccone Scott F SF Krueger Robert R Neuman Rosalind R Howells William W Fisher Sherri S Fox Louis L Cloninger Robert R Dick Danielle M DM Doheny Kimberly F KF Edenberg Howard J HJ Goate Alison M AM Hesselbrock Victor V Johnson Eric E Kramer John J Kuperman Samuel S Nurnberger John I JI Pugh Elizabeth E Schuckit Marc M Tischfield Jay J Rice John P JP Bucholz Kathleen K KK Bierut Laura J LJ
Addiction biology 20101104 3
Despite twin studies showing that 50-70% of variation in DSM-IV cannabis dependence is attributable to heritable influences, little is known of specific genotypes that influence vulnerability to cannabis dependence. We conducted a genome-wide association study of DSM-IV cannabis dependence. Association analyses of 708 DSM-IV cannabis-dependent cases with 2346 cannabis-exposed non-dependent controls was conducted using logistic regression in PLINK. None of the 948 142 single nucleotide polymorphi ...[more]
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