Ontology highlight
ABSTRACT:
SUBMITTER: Aspeslagh S
PROVIDER: S-EPMC3117654 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Aspeslagh Sandrine S Li Yali Y Yu Esther Dawen ED Pauwels Nora N Trappeniers Matthias M Girardi Enrico E Decruy Tine T Van Beneden Katrien K Venken Koen K Drennan Michael M Leybaert Luc L Wang Jing J Franck Richard W RW Van Calenbergh Serge S Zajonc Dirk M DM Elewaut Dirk D
The EMBO journal 20110506 11
Invariant natural killer T (iNKT) cells are known to have marked immunomodulatory capacity due to their ability to produce copious amounts of effector cytokines. Here, we report the structure and function of a novel class of aromatic α-galactosylceramide structurally related glycolipids with marked Th1 bias in both mice and men, leading to superior tumour protection in vivo. The strength of the Th1 response correlates well with enhanced lipid binding to CD1d as a result of an induced fit mechani ...[more]