Ontology highlight
ABSTRACT:
SUBMITTER: He R
PROVIDER: S-EPMC3117672 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
ChemMedChem 20101201 12
Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), is a major worldwide threat to public health. Mycobacterium protein tyrosine phosphatase B (mPTPB) is a virulent phosphatase secreted by Mtb, which is essential for the survival and persistence of the bacterium in the host. Consequently, small-molecule inhibitors of mPTPB are expected to serve as anti-TB agents with a novel mode of action. Herein, we report the discovery of highly potent and selective mPTPB inhibitors using ...[more]