Ontology highlight
ABSTRACT:
SUBMITTER: Wenzel DM
PROVIDER: S-EPMC3118098 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Wenzel Dawn M DM Stoll Kate E KE Klevit Rachel E RE
The Biochemical journal 20110101 1
Ubiquitination is a post-translational modification pathway involved in myriad cellular regulation and disease pathways. The Ub (ubiquitin) transfer cascade requires three enzyme activities: a Ub-activating (E1) enzyme, a Ub-conjugating (E2) enzyme, and a Ub ligase (E3). Because the E2 is responsible both for E3 selection and substrate modification, E2s function at the heart of the Ub transfer pathway and are responsible for much of the diversity of Ub cellular signalling. There are currently ov ...[more]