Ontology highlight
ABSTRACT:
SUBMITTER: Sankar MG
PROVIDER: S-EPMC5917230 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Sankar Muthukumar G MG Roy Sayantani S Tran Tuyen Thi Ngoc TTN Wittstein Kathrin K Bauer Jonathan O JO Strohmann Carsten C Ziegler Slava S Kumar Kamal K
ChemistryOpen 20180426 4
Complexity-generating chemical transformations that afford novel molecular scaffolds enriched in <i>sp</i><sup>3</sup> character are highly desired. Here, we present a highly stereoselective scaffold diversity synthesis approach that utilizes cascade double-annulation reactions of diverse pairs of zwitterionic and non-zwitterionic partners with 3-formylchromones to generate highly complex tetracyclic benzopyrones. Each pair of annulation partners adds to the common chroman-4-one scaffold to buil ...[more]