Ontology highlight
ABSTRACT:
SUBMITTER: Carvajal-Carmona LG
PROVIDER: S-EPMC3118761 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Carvajal-Carmona Luis G LG Cazier Jean-Baptiste JB Jones Angela M AM Howarth Kimberley K Broderick Peter P Pittman Alan A Dobbins Sara S Tenesa Albert A Farrington Susan S Prendergast James J Theodoratou Evi E Barnetson Rebecca R Conti David D Newcomb Polly P Hopper John L JL Jenkins Mark A MA Gallinger Steven S Duggan David J DJ Campbell Harry H Kerr David D Casey Graham G Houlston Richard R Dunlop Malcolm M Tomlinson Ian I
Human molecular genetics 20110429 14
We have previously identified several colorectal cancer (CRC)-associated polymorphisms using genome-wide association (GWA) analysis. We sought to fine-map the location of the functional variants for three of these regions at 8q23.3 (EIF3H), 16q22.1 (CDH1/CDH3) and 19q13.11 (RHPN2). We genotyped two case-control sets at high density in the selected regions and used existing data from four other case-control sets, comprising a total of 9328 CRC cases and 10 480 controls. To improve marker density, ...[more]