Ontology highlight
ABSTRACT:
SUBMITTER: Chang JW
PROVIDER: S-EPMC3119342 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Chemistry & biology 20110401 4
Cancer cells show alterations in metabolism that support malignancy and disease progression. Prominent among these metabolic changes is elevations in neutral ether lipids (NELs). We have previously shown that the hydrolytic enzyme KIAA1363 (or AADACL1) is highly elevated in aggressive cancer cells, where it plays a key role in generating the monoalkylglycerol ether (MAGE) class of NELs. Here, we use activity-based protein profiling-guided medicinal chemistry to discover a highly potent and selec ...[more]