Ontology highlight
ABSTRACT:
SUBMITTER: Lin AM
PROVIDER: S-EPMC3119764 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20110523 1
IL-17 and IL-23 are known to be absolutely central to psoriasis pathogenesis because drugs targeting either cytokine are highly effective treatments for this disease. The efficacy of these drugs has been attributed to blocking the function of IL-17-producing T cells and their IL-23-induced expansion. However, we demonstrate that mast cells and neutrophils, not T cells, are the predominant cell types that contain IL-17 in human skin. IL-17(+) mast cells and neutrophils are found at higher densiti ...[more]