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HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear.


ABSTRACT: HIV-1 transcription is regulated at the level of elongation by the viral Tat protein together with the cellular elongation factor P-TEFb, which is composed of cyclin T1 and Cdk9 subunits. The crystal structure of a Tat:P-TEFb complex (Tahirov, T.H.; Babayeva, N.D.; Varzavand, K.; Cooper, J.J.; Sedore, S.C.; and Price, D.H. Crystal structure of HIV-1 Tat complexed with human P-TEFb. Nature2010, 465, 747-751) reveals molecular details of Tat and its interactions that have eluded investigators for more than two decades and provides provocative insights into the mechanism of Tat activation.

SUBMITTER: D'Orso I 

PROVIDER: S-EPMC3120229 | biostudies-literature |

REPOSITORIES: biostudies-literature

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