Ontology highlight
ABSTRACT:
SUBMITTER: Henley JR
PROVIDER: S-EPMC3121244 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Henley John R JR Huang Kuo-hua KH Wang Dennis D Poo Mu-ming MM
Neuron 20041201 6
Cytoplasmic second messengers, Ca2+ and cAMP, regulate nerve growth cone turning responses induced by many guidance cues, but the causal relationship between these signaling pathways has been unclear. We here report that, for growth cone turning induced by a gradient of myelin-associated glycoprotein (MAG), cAMP acts by modulating MAG-induced Ca2+ signaling. Growth cone repulsion induced by MAG was accompanied by localized Ca2+ signals on the side of the growth cone facing the MAG source, due to ...[more]