Ontology highlight
ABSTRACT:
SUBMITTER: Goh EL
PROVIDER: S-EPMC2576245 | biostudies-other | 2008 Oct
REPOSITORIES: biostudies-other
Goh Eyleen L K EL Young Ju Kim JK Kuwako Kenichiro K Tessier-Lavigne Marc M He Zhigang Z Griffin John W JW Ming Guo-Li GL
Molecular brain 20081015
Several myelin-associated factors that inhibit axon growth of mature neurons, including Nogo66, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp), can associate with a common GPI-linked protein Nogo-66 receptor (NgR). Accumulating evidence suggests that myelin inhibitors also signal through unknown NgR-independent mechanisms. Here we show that MAG, a RGD tri-peptide containing protein, forms a complex with β1-integrin to mediate axonal growth cone turning respon ...[more]