Unknown

Dataset Information

0

Beta1-integrin mediates myelin-associated glycoprotein signaling in neuronal growth cones.


ABSTRACT: Several myelin-associated factors that inhibit axon growth of mature neurons, including Nogo66, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp), can associate with a common GPI-linked protein Nogo-66 receptor (NgR). Accumulating evidence suggests that myelin inhibitors also signal through unknown NgR-independent mechanisms. Here we show that MAG, a RGD tri-peptide containing protein, forms a complex with ?1-integrin to mediate axonal growth cone turning responses of several neuronal types. Mutations that alter the RGD motif in MAG or inhibition of ?1-integrin function, but not removal of NgRs, abolish these MAG-dependent events. In contrast, OMgp-induced repulsion is not affected by inhibition of b1-integrin function. We further show that MAG stimulates tyrosine phosphorylation of focal adhesion kinase (FAK), which in turn is required for MAG-induced growth cone turning. These studies identify ?1-integrin as a specific mediator for MAG in growth cone turning responses, acting through FAK activation.

SUBMITTER: Goh EL 

PROVIDER: S-EPMC2576245 | biostudies-other | 2008 Oct

REPOSITORIES: biostudies-other

altmetric image

Publications

beta1-integrin mediates myelin-associated glycoprotein signaling in neuronal growth cones.

Goh Eyleen L K EL   Young Ju Kim JK   Kuwako Kenichiro K   Tessier-Lavigne Marc M   He Zhigang Z   Griffin John W JW   Ming Guo-Li GL  

Molecular brain 20081015


Several myelin-associated factors that inhibit axon growth of mature neurons, including Nogo66, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp), can associate with a common GPI-linked protein Nogo-66 receptor (NgR). Accumulating evidence suggests that myelin inhibitors also signal through unknown NgR-independent mechanisms. Here we show that MAG, a RGD tri-peptide containing protein, forms a complex with β1-integrin to mediate axonal growth cone turning respon  ...[more]

Similar Datasets

| S-EPMC3121244 | biostudies-literature
| S-EPMC1395463 | biostudies-literature
| S-EPMC2818916 | biostudies-literature
| S-EPMC3115711 | biostudies-literature
| S-EPMC3133771 | biostudies-other
| S-EPMC4005724 | biostudies-literature
| S-EPMC2740462 | biostudies-literature
| S-EPMC2664087 | biostudies-literature
2022-08-01 | GSE175687 | GEO
| S-EPMC2173329 | biostudies-literature