Ontology highlight
ABSTRACT:
SUBMITTER: Wu N
PROVIDER: S-EPMC3121489 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Wu Ning N Castel David D Debily Marie-Anne MA Vigano Maria Alessandra MA Alibert Olivier O Mantovani Roberto R Iljin Kristina K Romeo Paul-Henri PH Gidrol Xavier X
The Journal of biological chemistry 20110410 23
The inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, ID2, acts as an oncogene and elevated levels of ID2 have been reported in several malignancies. Whereas some inducers of the ID2 gene have been characterized, little is known regarding the proteins capable to repress its expression. We developed siRNA microarrays to perform a large scale loss-of-function screen in human adult keratinocytes engineered to express GFP under the control of the upstream region of ID2 gene. We ...[more]