Ontology highlight
ABSTRACT:
SUBMITTER: Huang WC
PROVIDER: S-EPMC3121497 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Huang Wei-Chien WC Chen Yun-Ju YJ Li Long-Yuan LY Wei Ya-Ling YL Hsu Sheng-Chieh SC Tsai Shing-Ling SL Chiu Pei-Chun PC Huang Wei-Pang WP Wang Ying-Nai YN Chen Chung-Hsuan CH Chang Wei-Chao WC Chang Wen-Chang WC Chen Andy Jer-En AJ Tsai Chang-Hai CH Hung Mien-Chie MC
The Journal of biological chemistry 20110412 23
Epidermal growth factor receptor (EGFR), an aberrantly overexpressed or activated receptor-tyrosine kinase in many cancers, plays a pivotal role in cancer progression and has been an attractive target for cancer therapy. Gefitinib and erlotinib, two EGFR-tyrosine kinase inhibitors, have been approved for non-small cell lung cancer. However, durable clinical efficacy of these EGFR inhibitors is severely limited by the emergence of acquired resistance. For example, the expression of breast cancer- ...[more]