Ontology highlight
ABSTRACT:
SUBMITTER: Kawasaki F
PROVIDER: S-EPMC3121831 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Kawasaki Fumiko F Iyer Janani J Posey Lisa L LL Sun Chichun E CE Mammen Samantha E SE Yan Huaru H Ordway Richard W RW
Proceedings of the National Academy of Sciences of the United States of America 20110523 25
Members of the DISABLED (DAB) family of proteins are known to play a conserved role in endocytic trafficking of cell surface receptors by functioning as monomeric CLATHRIN-associated sorting proteins that recruit cargo proteins into endocytic vesicles. Here, we report a Drosophila disabled mutant revealing a novel role for DAB proteins in chemical synaptic transmission. This mutant exhibits impaired synaptic function, including a rapid activity-dependent reduction in neurotransmitter release and ...[more]