Ontology highlight
ABSTRACT:
SUBMITTER: Cardarelli L
PROVIDER: S-EPMC3121854 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Cardarelli Lia L Maxwell Karen L KL Davidson Alan R AR
Proceedings of the National Academy of Sciences of the United States of America 20110606 25
Altering the expression level of proteins that are subunits of complexes has been proposed to be particularly detrimental because the resulting stoichiometric imbalance among components would lead to misassembly of the complex. Here we show that assembly of the phage HK97 connector complex is severely inhibited by the overexpression of one of its component proteins, gp6. However, this effect is a result of the unusual mechanism by which the oligomerization and assembly of gp6 are controlled. Alt ...[more]