Ontology highlight
ABSTRACT:
SUBMITTER: Fornage M
PROVIDER: S-EPMC3122147 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Fornage Myriam M Debette Stephanie S Bis Joshua C JC Schmidt Helena H Ikram M Arfan MA Dufouil Carole C Sigurdsson Sigurdur S Lumley Thomas T DeStefano Anita L AL Fazekas Franz F Vrooman Henri A HA Shibata Dean K DK Maillard Pauline P Zijdenbos Alex A Smith Albert V AV Gudnason Haukur H de Boer Renske R Cushman Mary M Mazoyer Bernard B Heiss Gerardo G Vernooij Meike W MW Enzinger Christian C Glazer Nicole L NL Beiser Alexa A Knopman David S DS Cavalieri Margherita M Niessen Wiro J WJ Harris Tamara B TB Petrovic Katja K Lopez Oscar L OL Au Rhoda R Lambert Jean-Charles JC Hofman Albert A Gottesman Rebecca F RF Garcia Melissa M Heckbert Susan R SR Atwood Larry D LD Catellier Diane J DJ Uitterlinden Andre G AG Yang Qiong Q Smith Nicholas L NL Aspelund Thor T Romero Jose R JR Rice Kenneth K Taylor Kent D KD Nalls Michael A MA Rotter Jerome I JI Sharrett Richey R van Duijn Cornelia M CM Amouyel Philippe P Wolf Philip A PA Gudnason Vilmundur V van der Lugt Aad A Boerwinkle Eric E Psaty Bruce M BM Seshadri Sudha S Tzourio Christophe C Breteler Monique M B MM Mosley Thomas H TH Schmidt Reinhold R Longstreth W T WT DeCarli Charles C Launer Lenore J LJ
Annals of neurology 20110601 6
<h4>Objective</h4>White matter hyperintensities (WMHs) detectable by magnetic resonance imaging are part of the spectrum of vascular injury associated with aging of the brain and are thought to reflect ischemic damage to the small deep cerebral vessels. WMHs are associated with an increased risk of cognitive and motor dysfunction, dementia, depression, and stroke. Despite a significant heritability, few genetic loci influencing WMH burden have been identified.<h4>Methods</h4>We performed a meta- ...[more]