Ontology highlight
ABSTRACT:
SUBMITTER: Verhaaren BF
PROVIDER: S-EPMC4427240 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Verhaaren Benjamin F J BF Debette Stéphanie S Bis Joshua C JC Smith Jennifer A JA Ikram M Kamran MK Adams Hieab H HH Beecham Ashley H AH Rajan Kumar B KB Lopez Lorna M LM Barral Sandra S van Buchem Mark A MA van der Grond Jeroen J Smith Albert V AV Hegenscheid Katrin K Aggarwal Neelum T NT de Andrade Mariza M Atkinson Elizabeth J EJ Beekman Marian M Beiser Alexa S AS Blanton Susan H SH Boerwinkle Eric E Brickman Adam M AM Bryan R Nick RN Chauhan Ganesh G Chen Christopher P L H CP Chouraki Vincent V de Craen Anton J M AJ Crivello Fabrice F Deary Ian J IJ Deelen Joris J De Jager Philip L PL Dufouil Carole C Elkind Mitchell S V MS Evans Denis A DA Freudenberger Paul P Gottesman Rebecca F RF Guðnason Vilmundur V Habes Mohamad M Heckbert Susan R SR Heiss Gerardo G Hilal Saima S Hofer Edith E Hofman Albert A Ibrahim-Verbaas Carla A CA Knopman David S DS Lewis Cora E CE Liao Jiemin J Liewald David C M DC Luciano Michelle M van der Lugt Aad A Martinez Oliver O OO Mayeux Richard R Mazoyer Bernard B Nalls Mike M Nauck Matthias M Niessen Wiro J WJ Oostra Ben A BA Psaty Bruce M BM Rice Kenneth M KM Rotter Jerome I JI von Sarnowski Bettina B Schmidt Helena H Schreiner Pamela J PJ Schuur Maaike M Sidney Stephen S SS Sigurdsson Sigurdur S Slagboom P Eline PE Stott David J M DJ van Swieten John C JC Teumer Alexander A Töglhofer Anna Maria AM Traylor Matthew M Trompet Stella S Turner Stephen T ST Tzourio Christophe C Uh Hae-Won HW Uitterlinden André G AG Vernooij Meike W MW Wang Jing J JJ Wong Tien Y TY Wardlaw Joanna M JM Windham B Gwen BG Wittfeld Katharina K Wolf Christiane C Wright Clinton B CB Yang Qiong Q Zhao Wei W Zijdenbos Alex A Jukema J Wouter JW Sacco Ralph L RL Kardia Sharon L R SL Amouyel Philippe P Mosley Thomas H TH Longstreth W T WT DeCarli Charles C CC van Duijn Cornelia M CM Schmidt Reinhold R Launer Lenore J LJ Grabe Hans J HJ Seshadri Sudha S SS Ikram M Arfan MA Fornage Myriam M
Circulation. Cardiovascular genetics 20150207 2
<h4>Background</h4>The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk of stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings are incompletely characterized. To identify novel genetic variants influencing WMH burden, we conducted a meta-analysis of multiethnic genome-wide association studies.<h4>Methods and results</h4>We included 21 079 middle-aged to elderly individuals from 29 population-based cohorts, who were fre ...[more]