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ABSTRACT:
SUBMITTER: Triboulet S
PROVIDER: S-EPMC3123045 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Triboulet Sébastien S Arthur Michel M Mainardi Jean-Luc JL Veckerlé Carole C Dubée Vincent V Nguekam-Moumi Angèle A Gutmann Laurent L Rice Louis B LB Hugonnet Jean-Emmanuel JE
The Journal of biological chemistry 20110504 26
Peptidoglycan is predominantly cross-linked by serine DD-transpeptidases in most bacterial species. The enzymes are the essential targets of β-lactam antibiotics. However, unrelated cysteine LD-transpeptidases have been recently recognized as a predominant mode of peptidoglycan cross-linking in Mycobacterium tuberculosis and as a bypass mechanism conferring resistance to all β-lactams, except carbapenems such as imipenem, in Enterococcus faecium. Investigation of the mechanism of inhibition of t ...[more]