Ontology highlight
ABSTRACT:
SUBMITTER: Patterson KR
PROVIDER: S-EPMC3123074 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Patterson Kristina R KR Remmers Christine C Fu Yifan Y Brooker Sarah S Kanaan Nicholas M NM Vana Laurel L Ward Sarah S Reyes Juan F JF Philibert Keith K Glucksman Marc J MJ Binder Lester I LI
The Journal of biological chemistry 20110506 26
Neurofibrillary tangles, composed of insoluble aggregates of the microtubule-associated protein Tau, are a pathological hallmark of Alzheimer disease (AD) and other tauopathies. However, recent evidence indicates that neuronal dysfunction precedes the formation of these insoluble fibrillar deposits, suggesting that earlier prefibrillar Tau aggregates may be neurotoxic. To determine the composition of these aggregates, we have employed a photochemical cross-linking technique to examine intermolec ...[more]