Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau.
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ABSTRACT:
SUBMITTER: Lasagna-Reeves CA
PROVIDER: S-EPMC3463004 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau.
Lasagna-Reeves Cristian A CA Castillo-Carranza Diana L DL Sengupta Urmi U Guerrero-Munoz Marcos J MJ Kiritoshi Takaki T Neugebauer Volker V Jackson George R GR Kayed Rakez R
Scientific reports 20121003
Intracerebral injection of brain extracts containing amyloid or tau aggregates in transgenic animals can induce cerebral amyloidosis and tau pathology. We extracted pure populations of tau oligomers directly from the cerebral cortex of Alzheimer disease (AD) brain. These oligomers are potent inhibitors of long term potentiation (LTP) in hippocampal brain slices and disrupt memory in wild type mice. We observed for the first time that these authentic brain-derived tau oligomers propagate abnormal ...[more]
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