Rebuilding the damaged heart: the potential of cytokines and growth factors in the treatment of ischemic heart disease.
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ABSTRACT:
SUBMITTER: Beohar N
PROVIDER: S-EPMC3123891 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
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Rebuilding the damaged heart: the potential of cytokines and growth factors in the treatment of ischemic heart disease.
Beohar Nirat N Rapp Jonathan J Pandya Sanjay S Losordo Douglas W DW
Journal of the American College of Cardiology 20101001 16
Cytokine therapy promises to provide a noninvasive treatment option for ischemic heart disease. Cytokines are thought to influence angiogenesis directly via effects on endothelial cells or indirectly through progenitor cell-based mechanisms or by activating the expression of other angiogenic agents. Several cytokines mobilize progenitor cells from the bone marrow or are involved in the homing of mobilized cells to ischemic tissue. The recruited cells contribute to myocardial regeneration both as ...[more]
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