Ontology highlight
ABSTRACT:
SUBMITTER: Meza-Avina ME
PROVIDER: S-EPMC3124134 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Meza-Avina Maria Elena ME Wei Lianhu L Liu Yan Y Poduch Ewa E Bello Angelica M AM Mishra Ram K RK Pai Emil F EF Kotra Lakshmi P LP
Bioorganic & medicinal chemistry 20100409 11
In recent years, orotidine-5'-monophosphate decarboxylase (ODCase) has gained renewed attention as a drug target. As a part of continuing efforts to design novel inhibitors of ODCase, we undertook a comprehensive study of potent, structurally diverse ligands of ODCase and analyzed their structural interactions in the active site of ODCase. These ligands comprise of pyrazole or pyrimidine nucleotides including the mononucleotide derivatives of pyrazofurin, barbiturate ribonucleoside, and 5-cyanou ...[more]