Ontology highlight
ABSTRACT:
SUBMITTER: Nelson CA
PROVIDER: S-EPMC3124227 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Nelson Carol A CA Hunter R Bridge RB Quigley Lindsay A LA Girgenrath Stefan S Weber William D WD McCullough Jennifer A JA Dinardo Carol J CJ Keefe Kelly A KA Ceci Lorena L Clayton Nicholas P NP McVie-Wylie Alison A Cheng Seng H SH Leonard John P JP Wentworth Bruce M BM
The American journal of pathology 20110601 6
Respiratory function is the main cause of mortality in patients with Duchenne muscular dystrophy (DMD). Elevated levels of TGF-β play a key role in the pathophysiology of DMD. To determine whether therapeutic attenuation of TGF-β signaling improves respiratory function, mdx mice were treated from 2 weeks of age to 2 months or 9 months of age with either 1D11 (a neutralizing antibody to all three isoforms of TGF-β), losartan (an angiotensin receptor antagonist), or a combination of the two agents ...[more]