Ontology highlight
ABSTRACT:
SUBMITTER: Ganley IG
PROVIDER: S-EPMC3124681 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Ganley Ian G IG Wong Pui-Mun PM Gammoh Noor N Jiang Xuejun X
Molecular cell 20110601 6
Autophagy, a catabolic pathway that delivers cellular components to lysosomes for degradation, can be activated by stressful conditions such as nutrient starvation and endoplasmic reticulum (ER) stress. We report that thapsigargin, an ER stressor widely used to induce autophagy, in fact blocks autophagy. Thapsigargin does not affect autophagosome formation but leads to accumulation of mature autophagosomes by blocking autophagosome fusion with the endocytic system. Strikingly, thapsigargin has n ...[more]