Ontology highlight
ABSTRACT:
SUBMITTER: Godlewski J
PROVIDER: S-EPMC3125113 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Molecular cell 20100301 5
To sustain tumor growth, cancer cells must be able to adapt to fluctuations in energy availability. We have identified a single microRNA that controls glioma cell proliferation, migration, and responsiveness to glucose deprivation. Abundant glucose allows relatively high miR-451 expression, promoting cell growth. In low glucose, miR-451 levels decrease, slowing proliferation but enhancing migration and survival. This allows cells to survive metabolic stress and seek out favorable growth conditio ...[more]