Ontology highlight
ABSTRACT:
SUBMITTER: Poon Z
PROVIDER: S-EPMC3125426 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Poon Zhiyong Z Chang Dongsook D Zhao Xiaoyong X Hammond Paula T PT
ACS nano 20110429 6
Inspired by the simplicity and versatility of layer-by-layer (LbL) assembly, we applied multilayered polyelectrolyte assemblies on nanoparticles to create viable systemic delivery systems. Focusing on tumor-specific delivery, LbL nanoparticles that exhibit a pH-sensitive outer stealth layer are demonstrated to target and be retained in hypoxic tumor regions. The neutral layers shed in response to acidity to reveal a charged nanoparticle surface that is readily taken up by tumor cells. The first ...[more]