Ontology highlight
ABSTRACT:
SUBMITTER: Zhu S
PROVIDER: S-EPMC3946577 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Zhu Saijie S Niu Mengmeng M O'Mary Hannah H Cui Zhengrong Z
Molecular pharmaceutics 20130806 9
It is increasingly evident that tumor-associated macrophages (TAMs) play an important role in tumor invasion, proliferation, and metastasis. While delivery of drugs, imaging agents, and vaccines to TAMs was achieved by exploiting membrane receptors on TAMs, the uptake by normal macrophages remains an issue. In this communication, we report a PEG-sheddable, mannose-modified nanoparticle platform that can efficiently target TAMs via mannose-mannose receptor recognition after acid-sensitive PEG she ...[more]