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Common variants at 19p13 are associated with susceptibility to ovarian cancer.

ABSTRACT: Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 × 10?? and P = 6 × 10??, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 × 10?? and P = 4 × 10?¹¹, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.

SUBMITTER: Bolton KL 

PROVIDER: S-EPMC3125495 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

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Common variants at 19p13 are associated with susceptibility to ovarian cancer.

Bolton Kelly L KL   Tyrer Jonathan J   Song Honglin H   Ramus Susan J SJ   Notaridou Maria M   Jones Chris C   Sher Tanya T   Gentry-Maharaj Aleksandra A   Wozniak Eva E   Tsai Ya-Yu YY   Weidhaas Joanne J   Paik Daniel D   Van Den Berg David J DJ   Stram Daniel O DO   Pearce Celeste Leigh CL   Wu Anna H AH   Brewster Wendy W   Anton-Culver Hoda H   Ziogas Argyrios A   Narod Steven A SA   Levine Douglas A DA   Kaye Stanley B SB   Brown Robert R   Paul Jim J   Flanagan James J   Sieh Weiva W   McGuire Valerie V   Whittemore Alice S AS   Campbell Ian I   Gore Martin E ME   Lissowska Jolanta J   Yang Hanna P HP   Medrek Krzysztof K   Gronwald Jacek J   Lubinski Jan J   Jakubowska Anna A   Le Nhu D ND   Cook Linda S LS   Kelemen Linda E LE   Brooks-Wilson Angela A   Massuger Leon F A G LF   Kiemeney Lambertus A LA   Aben Katja K H KK   van Altena Anne M AM   Houlston Richard R   Tomlinson Ian I   Palmieri Rachel T RT   Moorman Patricia G PG   Schildkraut Joellen J   Iversen Edwin S ES   Phelan Catherine C   Vierkant Robert A RA   Cunningham Julie M JM   Goode Ellen L EL   Fridley Brooke L BL   Kruger-Kjaer Susan S   Blaeker Jan J   Hogdall Estrid E   Hogdall Claus C   Gross Jenny J   Karlan Beth Y BY   Ness Roberta B RB   Edwards Robert P RP   Odunsi Kunle K   Moyisch Kirsten B KB   Baker Julie A JA   Modugno Francesmary F   Heikkinenen Tuomas T   Butzow Ralf R   Nevanlinna Heli H   Leminen Arto A   Bogdanova Natalia N   Antonenkova Natalia N   Doerk Thilo T   Hillemanns Peter P   Dürst Matthias M   Runnebaum Ingo I   Thompson Pamela J PJ   Carney Michael E ME   Goodman Marc T MT   Lurie Galina G   Wang-Gohrke Shan S   Hein Rebecca R   Chang-Claude Jenny J   Rossing Mary Anne MA   Cushing-Haugen Kara L KL   Doherty Jennifer J   Chen Chu C   Rafnar Thorunn T   Besenbacher Soren S   Sulem Patrick P   Stefansson Kari K   Birrer Michael J MJ   Terry Kathryn L KL   Hernandez Dena D   Cramer Daniel W DW   Vergote Ignace I   Amant Frederic F   Lambrechts Diether D   Despierre Evelyn E   Fasching Peter A PA   Beckmann Matthias W MW   Thiel Falk C FC   Ekici Arif B AB   Chen Xiaoqing X   Johnatty Sharon E SE   Webb Penelope M PM   Beesley Jonathan J   Chanock Stephen S   Garcia-Closas Montserrat M   Sellers Tom T   Easton Douglas F DF   Berchuck Andrew A   Chenevix-Trench Georgia G   Pharoah Paul D P PD   Gayther Simon A SA  

Nature genetics 20100919 10

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 × 10⁻⁴ and P = 6 × 10⁻  ...[more]

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