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CoMet--a web server for comparative functional profiling of metagenomes.

ABSTRACT: Analyzing the functional potential of newly sequenced genomes and metagenomes has become a common task in biomedical and biological research. With the advent of high-throughput sequencing technologies comparative metagenomics opens the way to elucidate the genetically determined similarities and differences of complex microbial communities. We developed the web server 'CoMet' (http://comet.gobics.de), which provides an easy-to-use comparative metagenomics platform that is well-suitable for the analysis of large collections of metagenomic short read data. CoMet combines the ORF finding and subsequent assignment of protein sequences to Pfam domain families with a comparative statistical analysis. Besides comprehensive tabular data files, the CoMet server also provides visually interpretable output in terms of hierarchical clustering and multi-dimensional scaling plots and thus allows a quick overview of a given set of metagenomic samples.

SUBMITTER: Lingner T

PROVIDER: S-EPMC3125781 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

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CoMet--a web server for comparative functional profiling of metagenomes.

Lingner Thomas T Asshauer Kathrin Petra KP Schreiber Fabian F Meinicke Peter P

Nucleic acids research 20110526 Web Server issue

Analyzing the functional potential of newly sequenced genomes and metagenomes has become a common task in biomedical and biological research. With the advent of high-throughput sequencing technologies comparative metagenomics opens the way to elucidate the genetically determined similarities and differences of complex microbial communities. We developed the web server 'CoMet' (http://comet.gobics.de), which provides an easy-to-use comparative metagenomics platform that is well-suitable for the a ...[more]

PMID: 21622656

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