Analysis of prevalence of HIV-1 drug resistance in primary infections in the United Kingdom.

ABSTRACT:

Objectives

To identify changes since 1994 in the prevalence of resistance to anti-HIV drugs in primary HIV-1 infections in the United Kingdom.

Design

Retrospective and prospective assessment of viruses obtained from people recently infected with HIV.

Setting

Multiple centres (patients enrolled in the UK register of seroconverters) and a single large HIV clinic (active case ascertainment).

Participants

69 patients infected with HIV between June 1994 and August 2000.

Main outcome measures

Prevalence of key mutations associated with drug resistance in the reverse transcriptase and protease genes of HIV-1, by year of infection.

Results

Between June 1994 and August 2000, 10 (14%) of 69 newly infected patients had one or more key HIV-1 mutations associa

SUBMITTER: UK Collaborative Group on Monitoring the Transmission of HIV Drug Resistance 

PROVIDER: S-EPMC31258 | biostudies-literature | 2001 May

REPOSITORIES: biostudies-literature