Ontology highlight
ABSTRACT:
SUBMITTER: Cai L
PROVIDER: S-EPMC3126336 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Cai Lei L Loo Li Shen LS Atlashkin Vadim V Hanson Brendon J BJ Hong Wanjin W
Molecular and cellular biology 20110207 8
Phox (PX) domain-containing sorting nexins (SNXs) are emerging as important regulators of endocytic trafficking. Sorting nexin 27 (SNX27) is unique, as it contains a PDZ (Psd-95/Dlg/ZO1) domain. We show here that SNX27 is primarily targeted to the early endosome by interaction of its PX domain with PtdIns(3)P. Although targeted ablation of the SNX27 gene in mice did not significantly affect growth and survival during embryonic development, SNX27 plays an essential role in postnatal growth and su ...[more]