Ontology highlight
ABSTRACT:
SUBMITTER: Neal JA
PROVIDER: S-EPMC3126343 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Neal Jessica A JA Dang Van V Douglas Pauline P Wold Marc S MS Lees-Miller Susan P SP Meek Katheryn K
Molecular and cellular biology 20110207 8
How a cell chooses between nonhomologous end joining (NHEJ) and homologous recombination (HR) to repair a double-strand break (DSB) is a central and largely unanswered question. Although there is evidence of competition between HR and NHEJ, because of the DNA-dependent protein kinase (DNA-PK)'s cellular abundance, it seems that there must be more to the repair pathway choice than direct competition. Both a mutational approach and chemical inhibition were utilized to address how DNA-PK affects HR ...[more]