Ontology highlight
ABSTRACT:
SUBMITTER: Crickard JB
PROVIDER: S-EPMC7418177 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Crickard J Brooks JB Moevus Corentin J CJ Kwon Youngho Y Sung Patrick P Greene Eric C EC
Cell 20200604 6
Homologous recombination (HR) helps maintain genome integrity, and HR defects give rise to disease, especially cancer. During HR, damaged DNA must be aligned with an undamaged template through a process referred to as the homology search. Despite decades of study, key aspects of this search remain undefined. Here, we use single-molecule imaging to demonstrate that Rad54, a conserved Snf2-like protein found in all eukaryotes, switches the search from the diffusion-based pathways characteristic of ...[more]