Ontology highlight
ABSTRACT:
SUBMITTER: Ferrari G
PROVIDER: S-EPMC3126567 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Ferrari Guido G Pollara Justin J Kozink Daniel D Harms Tiara T Drinker Mark M Freel Stephanie S Moody M Anthony MA Alam S Munir SM Tomaras Georgia D GD Ochsenbauer Christina C Kappes John C JC Shaw George M GM Hoxie James A JA Robinson James E JE Haynes Barton F BF
Journal of virology 20110504 14
Among nonneutralizing HIV-1 envelope antibodies (Abs), those capable of mediating antibody-dependent cellular cytotoxicity (ADCC) activity have been postulated to be important for control of HIV-1 infection. ADCC-mediating Ab must recognize HIV-1 antigens expressed on the membrane of infected cells and bind the Fcγ receptor (FcR) of the effector cell population. However, the precise targets of serum ADCC antibody are poorly characterized. The human monoclonal antibody (MAb) A32 is a nonneutraliz ...[more]