Identification of autophagy genes participating in zinc-induced necrotic cell death in Saccharomyces cerevisiae.

ABSTRACT: Eukaryotes use a common set of genes to perform two mechanistically similar autophagic processes. Bulk autophagy harvests proteins nonselectively and reuses their constitutents when nutrients are scarce. In contrast, different forms of selective autophagy target protein aggregates or damaged organelles that threaten to interfere with growth. Yeast uses one form of selective autophagy, called cytoplasm-to-vacuole targeting (Cvt), to engulf two vacuolar enzymes in Cvt vesicles ("CVT-somes") within which they are transported to vacuoles for maturation. While both are dispensable normally, bulk and selective autophagy help sustain life under stressful conditions. Consistent with this view, knocking out several genes participating in Cvt and specialized autophagic pathways heightened the sensit

SUBMITTER: Dziedzic SA 

PROVIDER: S-EPMC3127211 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature