Ontology highlight
ABSTRACT:
SUBMITTER: Tan NS
PROVIDER: S-EPMC312855 | biostudies-literature | 2001 Dec
REPOSITORIES: biostudies-literature
Tan N S NS Michalik L L Noy N N Yasmin R R Pacot C C Heim M M Flühmann B B Desvergne B B Wahli W W
Genes & development 20011201 24
The immediate response to skin injury is the release of inflammatory signals. It is shown here, by use of cultures of primary keratinocytes from wild-type and PPAR beta/delta(-/-) mice, that such signals including TNF-alpha and IFN-gamma, induce keratinocyte differentiation. This cytokine-dependent cell differentiation pathway requires up-regulation of the PPAR beta/delta gene via the stress-associated kinase cascade, which targets an AP-1 site in the PPAR beta/delta promoter. In addition, the p ...[more]